EVALUATION OF INVOLVEMENT OF NEURO-CHEMICAL MECHANISM IN VALERIANA WALLICHII INDUCED ANTIDEPRESSANT EFFECT IN MICE

Objective: Valeriana (V) wallichii DC is found among the ground flora of Himalayan regions and used as herbal medicine for CNS disorders in Indian systems medicine. In study, aimed to investigation involvement neuro-chemical-systems V. induced antidepressant effects mice.
 Methods: The activity aqueous alcoholic extracts was measured by using Forced Swim Test Tail Suspension mice, whereas locomotor observed Actophotometer. Involvement adrenergic, dopaminergic serotonergic receptors mice were also observed.
 Results: Sub-acute administration showed significant (P<0.05) increase similar Imipramine, but did not show at lower doses FST. Whereas, pretreatment adrenergic receptor antagonist, antagonist serotonin synthesis inhibitor prevented induce anti-depressant effect mice. Lower hydoalcoholic extract interfering during sub-acute administration, a higher dose significantly decreases activity.
 Conclusion: Hence, it concluded that may mediate via systems.